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159. Khorshidi MA, Vanherberghen B, Kowalewski JM, Garrod KR, Lindström S, Andersson-Svahn H, Brismar H, Cahalan MD, Onfelt B. 2011.
Analysis of transient migration behavior of natural killer cells imaged in situ and in vitro.
Integrative  Biology 3: 770-778. pdf

158158. Cahalan, M.D. 2011.
Imaging transplant rejection: a new view.
Nature Medicine 6: 662-663. pdf

157157. Newton, R.H., S. Leverrier, S. Srikanth, Y. Gwack, M.D. Cahalan, and C.M. Walsh. 2010.
Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.
Journal of Immunology 186: 940-50. pdf

156156. Flach, H., M. Rosenbaum, M. Duchniewicz, S. Kim, S.L. Zhang, M.D. Cahalan, G. Mittler, and R. Grosschedl. 2010.
Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation innate-like B cells.
Immunity 33: 723-735. pdf suppdata

155155. Cahalan, M.D. 2010.
How to STIMulate calcium channels.
Science 330: 43-44. PMID: 20929798. pdf

154154. Krummel, M.F. and M.D. Cahalan. 2010.
The immunological synapse: a dynamic platform for local signaling.
Journal of Clinical Immunology 30: 364-372. PMID: 20390326. pdf

153153 .Sen, D., L. Forrest, T.B. Kepler, I. Parker, M.D. Cahalan. 2010
Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants.
Proceedings of the National Academy of Sciences U.S.A 107: 8334-9. pdf

152152. Garrod, K.R., F-C. Liu, L.E. Forrest, I. Parker, S-M. Kang, and M.D. Cahalan. 2010.
NK cell patrolling and elimination of donor-derived dendritic cells favors indirect alloreactivity.
Journal of Immunology 184: 2329-2336.  pdf

151. Garrod, K.R. and M.D. Cahalan. 2009.
Illuminating intranodal natural killer cell behaviour using two-photon microscopy.
In Natural Killer Cells, first edition. Michael Lotze and Angus Thomson, eds. Elsevier. 

150. Penna, A., S.L. Zhang, A.V. Yeromin, and M.D. Cahalan. 2009.
Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated by STIM and Orai.
In Ralph A. Bradshaw and Edward A. Dennis, editors: Handbook of Cell Signaling 2nd edition, Oxford:Academic Press,, pp. 209-216. 
149149. Cahalan, M.D. and K.G. Chandy. 2009.
The functional network of ion channels in T lymphocytes.
Immunological Reviews 231: 59-87.  pdf

Faculty of 1000 Biology
148148. Cahalan, M.D. 2009.
STIM-ulating store-operated Ca2+ entry.
Nature Cell Biology 11: 669-677. pdf

147147. Yu, Y., S.H. Keller, C.V. Remillard, O. Safrina, A. Nicholson, S.L. Zhang, W. Jiang, N. Vangala, J.W. Landsberg, J.Y. Wang, P.A. Thistlethwaite, R.N. Channick, I.M. Robbins, J.E. Loyd, H.A. Ghofrani, F. Grimminger, R.T. Schermuly, M.D. Cahalan, L.J. Rubin, and J.X. Yuan. 2009.
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary hypertension.
Circulation 119: 2313-2322 pdf
146146. Sen, D., T.J. Deerinck, M.H. Ellisman, I. Parker, and M.D. Cahalan. 2008..
Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo.
PLoS ONE ep 29;3(9):e3290. pdf

145145. Penna, A., A. Demuro, A.V. Yeromin, S.L. Zhang, O. Safrina, I. Parker, and M.D. Cahalan. 2008.
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.
Nature 456: 116-120. pdf

Faculty of 1000 Biology
144144. Matheu, M.P., C. Beeton, A. Garcia, V. Chi, K. Monaghan, M.I. Uemura, D. Li, S. Pal, L.M. de la Maza, E. Monuki, A. Flugel, M.W. Pennington, I. Parker, K.G. Chandy, and M.D. Cahalan. 2008.
Imaging of effector memory T cells during DTH and suppression by Kv1.3 channel block.
Immunity 29: 602-614. pdf

143143. Zhang, S.L., J.A. Kozak, W.Jiang, A.V. Yeromin, J. Chen, Y. Yu, A. Penna, W. Shen, V. Chi, and M.D. Cahalan. 2008.
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.
Journal of Biological Chemistry 283: 17662-17671. pdf

142142. Lioudyno, M.I., J.A. Kozak. A. Penna, O. Safrina, S.L. Zhang, D. Sen, J. Roos, K.A. Stauderman, and M.D. Cahalan. 2008.
Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.
Proceedings of the National Academy of Sciences  U.S.A. 105:2011-2016.  pdf

Faculty of 1000 Biology
141141. Cahalan, M.D. and I. Parker. 2008.
Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs.
Annual Review of Immunology 26: 585-626. pdf

140140. Oak, J.S., M.P. Matheu, I. Parker, M.D. Cahalan, and D.A. Fruman. 2007.
Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase.
Biochemical Society Transaction 35: 1109-1113. pdf

139139. Matheu, M.P., J.A. Deane, I. Parker, D.A. Fruman, and M.D. Cahalan. 2007.
Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. Journal of Immunology 179: 2261-2269.
Journal of Immunology 179: 2261-2269. pdf

Faculty of 1000 Biology
138138.Garrod, K.R., S.H. Wei, I. Parker, and M.D. Cahalan. 2007.
Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets.
Proceedings of the National Academy of Sciences U.S.A. 104: 12081-12086.    pdf

137137. Wei, S.H., O. Safrina, Y. Yu, K.R. Garrod, M.D. Cahalan, and I. Parker. 2007.
Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node.
Journal of Immunology 179: 1586-1594.  pdf

136136. Cahalan, M.D., S.L. Zhang, A.V. Yeromin, K. Ohlsen, J. Roos, and K.A. Stauderman. 2007.
Molecular basis of the CRAC channel.
Cell Calcium 42:133-144.   pdf

135135. Yeromin, A.V., S.L. Zhang, W. Jiang, Y. Yu, O. Safrina, and M.D. Cahalan. 2006.
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.
Nature 443:226-229.   pdf

Faculty of 1000 Biology

134134. Sanna, M.G., S.K. Wang, P.J. Gonzalez-Cabrera, A. Don, D. Marsolais, M.P. Matheu, S.H. Wei, I. Parker, E. Jo, W.C. Cheng, M.D. Cahalan, C.H. Wong, H. Rosen. 2006.
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.
Nature Chemical Biology 2:434-441.  pdf

Faculty of 1000 Biology

133133. Zhang S.L., A.V. Yeromin, X.H-F. Zhang, Y. Yu, O. Safrina, A. Penna, J. Roos, K.A. Stauderman, and M.D. Cahalan. 2006.
Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate CRAC channel activity.
Proceedings of the National Academy of Sciences U.S.A.103: 9357-9362.  pdf

132132. Cahalan, M.D. and I. Parker. 2006.
 Imaging the choreography of lymphocyte trafficking and the immune response. 
Current Opinion in Immunology 18:476-482.  pdf
131. Cahalan, M.D. and G.A. Gutman. 2006.
The sense of place in the immune system.
Nature Immunology 7: 329-332 pdf

130. Kozak, J.A., M. Matsushita, A.C. Nairn, and M.D. Cahalan. 2005.
Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition and rundown of TRPM7/MIC channels.
Journal of General Physiology 126: 499-514. pdf


129. Parker, I. and M.D. Cahalan. 2006
Immunology Based on Nonlinear Optical Microscopy.
In Handbook of Biological Nonlinear Microscopy. Oxford University Press,.

128. Cahalan, M.D. and I. Parker. 2005.
Close encounters of the first and second kind: T–DC and T–B interactions in the lymph node.
Seminars in Immunology 17: 442–451. pdf


127. Wei, S.H., H. Rosen, M.P. Matheu, M.G. Sanna, S-K. Wang, E. Jo, C-H Wong, I. Parker, and M.D. Cahalan. 2005.
S1P1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.
Nature Immunology 6, 1228 - 1235. pdf

  Faculty of 1000 Biology

126. Zhang S.L. Y. Yu, J. Roos, J.A. Kozak, T.J. Deerinck, M.H. Ellisman, K.A. Stauderman, and M.D. Cahalan. 2005.
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.
Nature 437: 902-905. pdf, supp figs

  Faculty of 1000 Biology

125. Zinselmeyer, B.H., Dempster, J., Gurney, A.M., Wokosin, D., Miller, M.J., Ho, H., Millington, O.R., Smith, K.M., Rush, C.M., Parker, I., Cahalan, M.D., Brewer, J.M., Garside, P. 2005.
In situ characterisation of CD4+ T cell behaviour in lymphoid tissues during the induction of oral priming and tolerance.
Journal of Experimental Medicine 201: 1815-1823. pdf


124. Roos, J. DiGregorio, P.J., A.V. Yeromin, K. Ohlsen, M. Lioudyno, S. Zhang, O. Safrina, J.A. Kozak, S. Wagner, M.D. Cahalan, G. Velicelebi, and K.A. Stauderman. 2005.
STIM1, an essential and conserved component of store-operated calcium channel function.
Journal of Cell Biology 169: 435-445. pdf

  Faculty of 1000 Biology

123. Okada, T., M.J. Miller, I. Parker, M.F. Krummel, M. Neighbors, S.B. Hartley, A. O’Garra, M.D. Cahalan, and J.G. Cyster.
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.
PLoS, Biology 3: 1047-061. pdf


  Faculty of 1000 Biology

122. Matsushita, M., J.A. Kozak, Y. Shimizu, D. McLachlin, H. Yamaguchi, F.Y Wei, K. Tomizawa, H. Matsui, B. Chait, M.D. Cahalan, A.C. Nairn. 2005.
Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/CHAK1.
Journal of Biological Chemistry 280: 20793-803. pdf


  121. Cahalan, M.D. 2005.
Stop! In the name of positive selection.
Nature Immunology 6: 126-128. pdf

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Jeff Ingeman
Physiology and Biophysics, University of California, Irvine, CA, USA, 92697-4561
Phone: (949) 824-
6754 • Fax: (949) 824-3143 • Email:mcahalan@uci.edu